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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3B
All Species:
36.06
Human Site:
S21
Identified Species:
61.03
UniProt:
P49841
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49841
NP_001139628.1
420
46744
S21
C
K
P
V
Q
Q
P
S
A
F
G
S
M
K
V
Chimpanzee
Pan troglodytes
XP_001164371
420
46753
S21
C
K
P
V
Q
Q
P
S
A
F
G
S
M
K
V
Rhesus Macaque
Macaca mulatta
XP_001110547
420
46919
S21
C
K
P
V
Q
Q
P
S
A
F
G
S
M
K
V
Dog
Lupus familis
XP_856611
420
46696
S21
C
K
P
V
Q
Q
P
S
A
F
G
S
M
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV60
420
46692
S21
C
K
P
V
Q
Q
P
S
A
F
G
S
M
K
V
Rat
Rattus norvegicus
P18266
420
46724
S21
C
K
P
V
Q
Q
P
S
A
F
G
S
M
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
S21
C
K
P
V
Q
Q
P
S
A
F
G
S
M
K
V
Frog
Xenopus laevis
NP_001083752
420
46885
S21
C
K
P
V
Q
Q
P
S
S
F
G
S
M
K
V
Zebra Danio
Brachydanio rerio
NP_571456
421
46854
S21
C
K
P
V
P
Q
P
S
A
F
G
S
M
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
K572
Q
S
C
V
S
W
T
K
V
V
Q
K
F
K
N
Honey Bee
Apis mellifera
XP_392504
434
48445
H30
G
G
M
R
V
S
S
H
P
A
G
G
V
T
L
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
K39
E
M
K
I
K
D
D
K
E
M
E
A
A
V
V
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
94.7
99.7
N.A.
99
98.8
N.A.
N.A.
93.7
93.3
95
N.A.
31.8
70.9
64.7
N.A.
Protein Similarity:
100
98.8
96.4
99.7
N.A.
99
99
N.A.
N.A.
95.1
97.1
97.1
N.A.
34.9
80.4
74.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
93.3
93.3
N.A.
13.3
6.6
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
13.3
20
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60.2
44.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
58
8
0
8
8
0
0
% A
% Cys:
65
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
65
0
0
8
0
0
% F
% Gly:
8
8
0
0
0
0
0
0
0
0
72
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
65
8
0
8
0
0
15
0
0
0
8
0
72
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% L
% Met:
0
8
8
0
0
0
0
0
0
8
0
0
65
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
65
0
8
0
65
0
8
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
58
65
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
8
8
8
65
8
0
0
65
0
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% T
% Val:
0
0
0
72
8
0
0
0
8
8
0
0
8
8
72
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _